Cellular and Molecular Microbial Pathogenesis:
The Host/Pathogen Interplay (BioMS 4340)
This undergraduate course will integrate the immune response of the host to challenges from medically important pathogens, including viruses, parasites and bacteria, to provide a unified view of microbial pathogenesis. The lectures will integrate concepts from the disciplines of immunology, bacteriology, virology, and parasitology, to cover aspects of host cell biology and the innate and acquired immune responses of the host to infection. A range of medically relevant human and animal pathogens will be detailed, focusing on the host's response to commensalism versus disease, the mechanisms of host invasion, nutrient acquisition, and modulation of the host's immune response. The course will also discuss current disease interventions and the challenges facing antimicrobial therapy and vaccine development. This integrated and comparative view of the cellular and molecular interaction between infectious agents and the host's immune response will be a capstone of the student's exposure to infection biology. Outcome 1: Identify and distinguish the approaches viruses, bacteria and parasites use to counteract or interact with components of the host immune response to allow their replication and spread. Outcome 2: Integrate at a cellular and molecular level the host's response to prevent infections with the strategies infectious agents employ to overcome host.
Principles of Virology (BioMI 4090/VetMI 4090/PLPA4090)
This undergraduate course covers the principles of virology, focusing mainly on animal viruses but also including plant viruses and bacteriophage. Topics include the classification of viruses, virus entry, genome replication and assembly, and virus pathogenesis. Particular emphasis is placed on virus-host cell interactions and common features between different viral families. 3 credits. Prerequisites: BioMI 290 & 291 or permission of instructor.
The Biology of Plant and Animal Viruses (VetMI 7000)
This graduate course covers topics that are more selective and taught in greater depth than in the 409 course. It examines current topics in studies of animal viruses, as well as studies of some plant viruses. After a brief introduction to the general properties of viruses, selected topics that are of contemporary interest in virology are examined in depth. Topics to be explored include the structures of viruses and their components; selected viral replication strategies; viral evolution and selection; the cell biology of the interactions between viruses and cells; novel approaches to vaccine development; methods for antiviral chemotherapy; and the use of viruses in gene therapy approaches. Many topics will be covered from examples or well established model systems. References are given to review articles on the various topics discussed and literature references to greater depth of some subject areas will also be given during the sessions.
The following courses often contain virology content:
- BIOMS 3150 Basic Immunology
- VETMI/BIOMS 7050 Advanced Immunology
- VETMI/BIOMS 7190 Immunology of INfectious Disease
- VETMI 7250 Mechanisms of Microbial Pathogeneis
- VETMI 7120 Seminars in Infection and Immunity (seminar)
- VETMI 7230 Current Topics in Immunology and infectious Disease (Journal Club)
- VETMI 7251 Current Topics in Microbial Pathogeneis (Journal Club)
- VETMI 7070 Advanced Work in Bacteriology, Virology, and Immunology (Independent Study)